Naučnoistraživački radovi i prezentacije
Publications
11. Deep learning of functional perturbations from condensate morphology.
Donlic, A.; Comi, T.; Quinodoz, S.A.; Jaberi-Lashkari, N.; Antunes-Fernandes, K.; Jiang, L.; Wiesner, L.W.; Lim, A.I.; Brangwynne, C.P. bioRxiv preprint. DOI:10.1101/2025.08.18.670955.
10. Metabolism of epigenetic ribonucleosides leads to nucleolar stress and cytotoxicity.
Sun, X.; Donlic, A.; Boyer, J.A.; Reddy, N.; Brangwynne, C.P.; Rabinowitz, J.D.; Kleiner, R.E. bioRxiv preprint. DOI:10.1101/2025.06.11.659152.
9. Mapping and engineering RNA-controlled architecture of the multiphase nucleolus.
Quinodoz, S.A.;* Jiang, L.;* Abu-Alfa A.; Comi, T.; Zhao, H.; Yu, Q.; Wiesner, L.; Donlic, A.; Soehalim, E.; Zorbas, C.; Wacheul, L.; Kosmrlj, A.; Lafontaine, D. L.J.; Klinge, S.; Brangwynne, C.P. Nature 2025, 64, 557-566. DOI:10.1038/s41586-025-09207-4
8. Viscoelastic RNA entanglement and advective flow underlie nucleolar form and function.
Riback, J.A.*; Eeftens, J.M.*; Lee, D.S.W.*; Quinodoz, S.A.; Donlic, A.; Orlovsky, N.; Wiesner, L.; Beckers, L.; Becker, L.A.; Strom, A.; Rana, U.; Tolbert, M.; Kleiner, R.; Kriwacki, R.; Brangwynne, C.P. Molecular Cell 2023, 83, 3095-3107. DOI:10.1016/j.molcel.2023.08.006
7. SARS-CoV-2 Requires Chloesterol for Viral Entry and pathological Syncytia Formation.
Sanders, D.W.; Jumper, C.C.; Ackerman, P.J.; Bracha, D.; Donlic, A.; Kim, H.; Kenney, D.; Castello-Serrano I.; Suzuki, S.; Tamura T.; Tavares, A.H.; Saeed, M.; Holehouse, A.S.; Ploss, A.; Levental, I.; Douam, F.; Padera, R.F.; Levy, B.D.; and Brangwynne, C.P. eLife 2021, 10:e65962. DOI:10.7554/eLife.65962
Featured in News Medical Life Sciences, Howard Hughes Medical Institute News, and Frankfurter Rundschau
6. R-BIND 2.0: An Updated Database of Bioactive RNA-Targeting Small Molecules and Associated RNA Secondary Structures.
Donlic, A.*, Swanson, E.*, Wicks, S., Chiu, L.Y., Juru, A.U., Cai, Z., Kassam, K., Lauderman, K., Sanaba, B., Tolbert, B., and Hargrove, A. E. ACS Chemical Biology 2022, 17, 1556-1566. DOI:10.1021/acschembio.2c00224
5. Targeting RNA with small molecules: from fundamental principles towards the clinic.
Falese, J.; Donlic, A.; Hargrove, A. E. Chemical Society Reviews 2021, 50, 2224-2243. DOI:10.1039/D0CS01261K
4. Regulation of MALAT1 triple helix stability and in vitro degradation by diphenylfurans.
Donlic, A.; Zafferani, M.; Padroni, G.; Puri, M.; Hargrove, A. E. Nucleic Acids Research 2020, gkaa585. DOI:10.1093/nar/gkaa585
3. R-BIND : An Interactive Database for Exploring and Developing RNA-Targeted Chemical Probes.
Morgan, B.S.; Sanaba, B.; Donlic, A.; Karloff, D.; Forte, J. E.; Zhang, Y; Hargrove, A. E. ACS Chemical Biology 2019, 14, 2691-2700. DOI:10.1021/acschembio.9b00631
2. Discovery of Small Molecule Ligands for MALAT1 by Tuning an RNA-binding Scaffold.
Donlic, A.; Morgan, B.S.; Xu, J. L.; Liu, A.; Roble Jr., C.; Hargrove, A. E. Angew. Chem. Int. Ed. 2018, 130 (40), 13426-13431. DOI: 10.1002/anie.201808823
Faculty 1000 Recommendation: Chen, G. and Edwards, N: F1000Prime Recommendation of Evaluation [Donlic A et al., Angew Chem Int Ed Engl 2018 57(40):13242-13247]. In F1000Prime, 21 Nov 2018; 10.3410/f.733852452.793552881
1. Targeting RNA in Mammalian Systems with Small Molecules.
Donlic, A.; Hargrove, A. E. Wiley Interdisciplinary Reviews: RNA 2018, 9: (4) e1477. DOI: 10.1002/wrna.1477
Featured in Advanced Science News
Top Ten Most Downloaded and Cited Article in Journal 2017 – 2018; 2018 – 2019; 2019-2020; 2020-2021
Selected Presentations
Anita Donlic, Troy Comi, Sofia Quinodoz, Nima Jaberi-Lashkari, Krist Antunes-Fernandes, Lifei Jiang, Lennard Wiesner, Ai Ing Lim, Clifford Brangwynne. "Deep Learning-Driven Profiling of Biomolecular Condensate Images Reveals Mesoscale Structure-Molecular Function Relationships. ”; Keystone Symposia – AI in Molecular Biology. Santa Fe, NM. Sep 17th, 2025.
Anita Donlic, Troy Comi, Sofia Quinodoz, Nima Jaberi-Lashkari, Krist Antunes-Fernandes, Lifei Jiang, Lennard Wiesner, Ai Ing Lim, Clifford Brangwynne. "Quantitative Profiling of Nucleolar Structure Reveals a Novel Role for a DNA Topoisomerase in rRNA Processing. ”; Nucleic Acids Gordon Research Conference. Lucca, Italy. Jun 22 – 27, 2025. (best poster award)
Anita Donlic, Troy Comi, Lifei Jiang, Sofia Quinodoz, Clifford Brangwynne. "A Chemical Biology Toolkit to Understand and Target Biomolecular Condensates.”; 5th International Congress of Chemists and Chemical Engineers of B&H. Sarajevo, Bosnia and Herzegovina. June 28th, 2024. (invited keynote oral presentation)
Anita Donlic, Elizabeth Zheleznyakova, Lennard Wiesner, Clifford Brangwynne. "Linking Molecular-Level RNA-Protein Interactions with Mesoscale Properties of the Nucleolus.”; Biophysical Society Annual Meeting, Intrinsically Disordered Proteins Symposium. San Diego, CA. February 18th, 2023. (invited oral presentation, Postdoctoral Talk Award)
Anita Donlic, Sofia Quinodoz, and Amy Strom. "Nuclear Phase Separation in Cancer: Integrating Multidisciplinary approaches across scales.”; Genentech Future of Oncology Virtual Research Symposim. Virtual. May 18th, 2022. (invited oral presentation)
Anita Donlic, Malavika Puri, Brittany S. Morgan, Jason Xu, Giacomo Padroni, Emily J. McFadden, Carlos Roble, and Amanda E. Hargrove. "Developing chemical tools and approaches for the study of an oncogenic long non-coding RNA”; HHMI Janelia Junior Scientist Workshop for Solving Biological Problems with Chemistry. Ashburn, VA. July 31st, 2019. (oral presentation)
Anita Donlic, Giacomo Padroni, Martina Zaferrani, and Amanda E. Hargrove. “Next-generation diphenylfurans provide insights into the determinants of MALAT1 triple helix binding and stability”; Bioorganic Chemistry Gordon Research Seminar and Conference. Andover, NH. Jun 9 – Jun 14, 2019. (poster)
Anita Donlic, Brittany S. Morgan, Jason Xu, Angela Liu, Carlos Roble Jr., and Amanda E. Hargrove. “Tuning an RNA-binding scaffold for specific recognition of the MALAT1 triple helix”; Carolina Biophysics Symposium. Chapel Hill, NC. October 26th, 2018. (poster)
Anita Donlic, Jason Xu, Angela Liu, Carlos Roble, Emily J. McFadden, Malavika Puri, and Amanda E. Hargrove. “Utilizing small molecule tools to identify and target structural motifs in an oncogenic long non-coding RNA”; 256th ACS National Meeting. Division of Biological Chemistry; Graduate Student & Postdoctoral Fellow Symposium. Boston, MA. August 20, 2018. (oral presentation)
Anita Donlic, Brittany S. Morgan, Jason Xu, Angela Liu, Carlos Roble Jr., and Amanda E. Hargrove. “Tuning an RNA-binding scaffold for specific recognition of the MALAT1 triple helix”; 6th Annual North Carolina Biosciences Collaborative Research Symposium. Durham, NC. July 27th, 2018. (poster)
Anita Donlic, Jason Xu, Angela Liu, Carlos Roble, and Amanda E. Hargrove. “Development of chemical probes and high-throughput screens to target an oncogenic RNA triple helix.”; 2017 Symposium on RNA Biology XII: RNA Tool and Target. Chapel Hill, NC. October 19, 2017. (poster)
Anita Donlic, Jason Xu, Angela Liu, Carlos Roble, and Amanda E. Hargrove. “A Chemical Biology Approach to Study the Role of an RNA Triple Helix in Oncogenic Processes.”; Duke University Graduate Chemistry Research Symposium. Durham, NC. October 9, 2017. (oral presentation; Best Lightning Talk Award )
Anita Donlic, Jason Xu, Angela Liu, Carlos Roble, and Amanda E. Hargrove. “Development of chemical probes and high-throughput screens to target an oncogenic RNA triple helix.”; Sci-Mix Poster Session, American Chemical Society National Meeting. Washington, DC. August 21, 2017. (selected poster)
Anita Donlic, Jason Xu, Angela Liu, Carlos Roble, and Amanda E. Hargrove. “Targeting the MALAT1 triple helix: development of chemical probes and high throughput screens”; National Cancer Institute RNA Biology Symposium. Bethesda, MD. April 24, 2017. (poster)
Anita Donlic, Jason Xu, Angela Liu, Carlos Roble, and Amanda E. Hargrove. “A Chemical Biology Approach to Target an Oncogenic Triple Helix”; Duke University Structural Biology and Biophysics Seminar Series. Durham, NC. April 17, 2017. (oral presentation)